Researchers have analysed the capabilities in mice after spotting a human subject who was able to regrow part of a rib.
The team found that mice and humans were able to regrow removed ribs within months.
In a new
study in the Journal of Bone and Mineral Research, a team directed by
USC Stem Cell researcher Francesca Mariani studied the phenomenon.
Using CT imaging, the team monitored the healing of a human rib that had been partially removed by a surgeon.
The eight centimeters of missing bone and one centimeter of missing cartilage did partially repair after six months.
To
better understand this repair process, they removed sections of rib
cartilage — ranging from three to five millimeters — from a related
mammal, mice.
They also
found that a perichondrium retains the ability to produce cartilage even
when disconnected from the rib and displaced into nearby muscle tissue —
further suggesting that the perichondrium contains progenitor or stem
cells.
'We
believe that the development of this model in the mouse is important
for making progress in the field of skeletal repair, where an acute
clinical need is present for ameliorating skeletal injury, chronic
osteoarthritis and the severe problems associated with reconstructive
surgery,' said Mariani, assistant professor of Cell and Neurobiology and
principal investigator in the Eli and Edythe Broad Center for
Regenerative Medicine and Stem Cell Research at USC.
'At
the early stages in our understanding, the mouse provides us with an
exceptional ability to make progress, and we are excited about the
potential for using cells derived from the rib perichondrium or using
rib perichondrium-like cells for regenerative therapy.'
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